Dr Goodenowe / Prodrome Sciences

Dayan Goodenowe is a PhD Neuroscientist, Chemist and Biochemist. He is an expert on the biochemical mechanisms and epidemiology of disease. Dr Goodenowe is the founder of Prodrome Sciences Inc.

Dr Goodenowe’s Breaking Alzheimer’s book, published in June 2021 is the story of how 15 years of research into biochemical mechanisms of neurological disease led to the discovery that low plasmalogen levels are a key factor in cognitive decline.

Plasmalogens are important components of membranes that are key to neurotransmitter release and support cellular communication. Found in high concentrations in the brain and heart they are synthesised in the liver, however, there are no food sources that deliver sufficient levels (in part due to being very sensitive to being broken down by stomach acid).  Resistance training however can support endogenous plasmalogen production. As we age our ability to create plasmalogens declines.

Studies show that plasmalogen levels are low in those with cognitive decline such as Dementia and Alzheimer’s and neurodegenerative diseases such as Parkinsons’s and Multiple Sclerosis. Research has also shown that levels are also low in Colorectal, Pancreatic, Breast and Ovarian Cancer, Heart Disease, Stroke and Diabetes.

Plasmalogens are membrane phospholipids. They have antioxidant properties and comprise fatty acids such as oleic acid and DHA.


Prodrome Sciences have developed the ProdromeScan blood test that measures key biosystem sufficiencies including phospholipids, plasmalogens and fatty acids/gastrointestinal tract acids. 

The ProdromeScan blood test covers 14 sections:


Section 1 - 4

Membrane Phospholipids


Dietary Fatty Acids


Gastrointestinal Tract Acids (GTAs)


Iron Sufficiency


Methyltransferase / Choline System


Mitochondrial Function




Elongase 5 Activity


Peroxisomal Activity


Cholesterol Transport


Kidney Function

Plasmalogen Plus

The Plasmalogen Plus blood test considers just the Plasmalogens and Phosphatidyl Ethanolamines.

The Prodrome testing forms part of what Dr Goodenowe terms a three step ‘living systems’ programme;

  1. Exercise to work muscles to support plasmalogen synthesis 
  2. A balanced diet that includes intermittent fasting to allow time for clean up processes to happen that also support a balanced antioxidant capacity
  3. Tracking biochemistry foundation and then progress with testing

This is something that anyone can do, especially with support from a Practitioner to optimise their health.

Dr Goodenowe has a Certification course for Healthcare Practitioners and a range of supplements, including Plasmalogen supplements.

In 2021 the ProdromeScan Certification Course was launched and we highly recommend this Course to become a Certified Professional.

The course is self-paced with 10 modules:

Module 1

Introduction to Biochemical Prodromes of Health and Disease

Module 2

The Biochemistry of Life and Death

Module 3

The Biochemistry of Alzheimer’s and Dementia

Module 4

The Biochemistry of Plasmalogen Restoration and Augmentation

Module 5

The Biochemistry of Parkinson’s Disease

Module 6

The Biochemistry of Autism

Module 7

The Biochemistry of Multiple Sclerosis and ALS

Module 8

The Biochemistry of Cardio and Cerebral Vascular Disease

Module 9

The Biochemistry of Cancer

Module 10

ProdromeScan Report Interpretation Tutorial

The training supports Practitioners’ ability to work with the ProdromeScan testing and supplementation options and to experience intensive learning to deliver targeted lifestyle, supplementation and dietary strategies for their clients.

Ongoing Roundtable Group meetings cement the ongoing learning and allow for discussion of case studies.