Neuroquant is an FDA approved tool for accurate brain volume assessment, typically run on a T1 volumetric MRI brain imaging profile.
A 3D T1 Saggital MP-RAGE protocol sequence is required to run the imaging report. NeuroQuant is preferred by Dr Shoemaker in his work reporting on atrophy and oedema changes in the brain relating to biotoxin exposure.
See sample report for further details.
References
Ross DE, Ochs AL, Seabaugh JM, Shrader CR; Alzheimer's Disease Neuroimaging Initiative. Man versus machine: comparison of radiologists™ interpretations and NeuroQuant® volumetric analyses of brain MRIs in patients with traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2013;25(1):32- 39. doi:10.1176/appi.neuropsych.11120377
McMahon, SW, MD, Shoemaker RC, MD, Ryan JC PhD, Reduction in Forebrain Parenchymal and Cortical Grey Matter Swelling across Treatment Groups in Patients with Inflammatory Illness Acquired Following Exposure to Water-Damaged Building. J Neurosci Clin Res Vol, Issue 1
Neuroreader is an MRI imaging report, which utilises processing software intended for volumetric quantification of identifiable brain structures. A 3D T1 Saggital MP-RAGE protocol sequence is required to run the imaging report. Thickness of slides should be as close to 1mm (max 1.2mm) with no gap between slides. Whole brain should be present with no folding effect.
Neuroreader is preferred by Dr Dale Bredesen in his work on Alzheimer's with atrophy showing in key areas of the brain associated with cognitive changes.
See sample report for further details
References
Ahdidan, J, Raji, CA, De You EA, Mathis J et al. Quantative Neuroimaging Software for Clinical Assessment of Hippocampal Volumes on MR Imaging. Journal of Alzheimer's Disease 49 (2016) 723- 732
Raji, Cyrus A, MD, PhD, Ly, Maria BS, Benzinger, Tammie LS, MS PhD. Overview of MR Imaging Vol- umetric Quantification in Neurocognitive Disorders, Topics in Magnetic Resonance Imaging: Dec 2019, Vol 8, Issue 6 p311-315